Yale researchers have discovered that certain prescription drugs, healthy diets, and exercise can measurably slow biological aging, while popular anti-aging supplements appear largely ineffective. Their analysis of 51 studies could transform how scientists evaluate anti-aging treatments, although whether these biological changes actually extend life remains uncertain.

A study of more than 750,000 pregnancies found that early exposure to Ozempic, Wegovy, and similar drugs was not linked to increased pregnancy complications when used for weight loss, but was associated with a higher risk of premature birth when prescribed for diabetes. The surprising difference suggests that diabetes itself may be driving the risk, although researchers caution that the drugs' safety during pregnancy remains uncertain.

New research involving more than 440,000 Americans links cannabis use to increased cardiovascular risk, with occasional users showing 40% higher odds of reporting a history of stroke. The findings suggest that even infrequent marijuana use may warrant concern, although researchers have not established that cannabis directly causes strokes or heart disease.

A study of more than 17,700 US adults found that people who use cannabis in multiple forms have dramatically higher rates of daily consumption and addiction symptoms than those who stick primarily to one method. Nearly 67% of those who used almost every form met criteria for cannabis use disorder, compared with just 15% of people who mainly consumed edibles.

A surprising discovery reveals how psilocybin, the active compound in magic mushrooms, rapidly reshapes the brain by creating new neural connections and strengthening them. Researchers found that the drug behaves differently in healthy and chronically stressed mice, potentially helping repair brain circuits damaged by prolonged stress. Most intriguingly, they identified a way to trigger this brain rewiring without the behavioral response associated with psychedelic effects.

A major new review challenges the growing enthusiasm for medical cannabis as an insomnia treatment, finding little reliable evidence that it improves sleep quality, sleep duration, or daytime functioning. Researchers caution that this doesn't mean cannabis is ineffective, only that existing studies are too weak to establish whether it works.

A cannabis-derived ingredient commonly found in sleep gummies may be more habit-forming than previously thought, with new research showing that repeated exposure caused tolerance and withdrawal symptoms in mice. Scientists warn that CBN may carry risks similar to THC, although its long-term effects in humans remain largely unknown.

Researchers have uncovered a hidden immune defense capable of attacking small cell lung cancer, an extremely aggressive disease that often escapes conventional treatments. The specialized immune cells can recognize and destroy cancer cells even when tumors have disguised themselves from the immune system.

A simple, steroid-free procedure could offer lasting relief for people struggling with carpal tunnel syndrome, potentially helping them avoid surgery. In a clinical trial involving 63 patients, researchers found that ultrasound-guided hydrodissection, which uses fluid to free a compressed nerve in the wrist, provided longer-lasting improvements in pain, numbness, and hand function than traditional steroid injections.

Scientists have discovered that many common sweeteners can interfere with gut bacteria, with some combinations involving medications producing surprisingly strong effects. One sweetener mixed with a widely prescribed antidepressant reduced beneficial bacteria and microbial diversity in laboratory experiments, raising new questions about potential effects on gut health and immunity.

Scientists have discovered that vanillin, the compound that gives vanilla its distinctive flavor, has powerful properties that could help fight infections, reduce inflammation, and promote wound healing. The inexpensive, widely available ingredient could one day become an important component of advanced wound treatments and regenerative medicine.

Depression may not be one biological condition, but several distinct patterns of brain activity hiding under the same diagnosis. Researchers studying 263 people with depression identified five brain profiles, each showing different patterns of communication between brain regions and associations with symptoms such as anxiety, trauma, and substance abuse.

Researchers at Yale have identified a promising new approach to osteoarthritis that could do more than simply ease pain. The epilepsy drug lacosamide appears to block a protein involved in both pain signaling and cartilage destruction, helping damaged joints shift back toward repair in preclinical studies.

Cannabinoids may intensify anxiety by removing a natural brake on specific neurons in the brain’s fear center, particularly during stressful situations. In mice, shutting down those neurons sharply reduced cannabinoid-related anxious behavior.

A review of more than 265,000 people found that cannabis use was associated with higher rates of both committing violence and becoming a victim of it. The researchers say the link is significant but does not prove cannabis itself is the cause.

A massive MRI study found that Alzheimer’s disease, mild cognitive impairment, psychiatric disorders, and addiction are associated with distinct patterns of accelerated brain aging. The strongest effects appeared in Alzheimer’s and mild cognitive impairment, while ADHD and autism showed no significant overall difference.

Scientists discovered rare flavoalkaloids in Cannabis leaves for the first time, along with dozens of other phenolic compounds that had never been reported in the plant. The findings suggest that Cannabis leaves, often discarded as waste, may contain a surprisingly rich source of potentially useful chemicals.

Researchers have found evidence that long COVID may damage dopamine releasing neurons in the brain, potentially explaining persistent fatigue, low motivation, slowed movement, and memory difficulties. The discovery could lead to new treatments that target the brain's dopamine system.

A major Ontario study found 24 common medication chains in which one drug’s side effects can be mistaken for a new medical problem, leading to another prescription. Researchers say closer medication reviews, pharmacist involvement, and automated alerts could help prevent these potentially harmful prescribing cascades.

Scientists in Japan have identified a natural compound found in blueberries, grapes, and other berries that may help muscle cells burn excess fat instead of storing it. The compound, pterostilbene, reduced abnormal fat buildup in cultured mouse muscle cells by boosting fat breakdown and helping stabilize a key protein involved in fatty acid metabolism.