Drug Facts in Media

A combination of two medications, injectable naltrexone and oral bupropion, was safe and effective in treating adults with moderate or severe methamphetamine use disorder in a double-blind, placebo-controlled Phase III clinical trial. The findings suggest this combination therapy may be a promising addition to current approaches to treatment, such as cognitive behavioral therapy and contingency management interventions, for a very serious condition that remains difficult to treat and overcome.

Marijuana use increases throughout the calendar year, with use up 13 percent on average at the end of each year compared to the beginning.

Scientists have uncovered new evidence of the potential health risks of chemicals in tobacco and marijuana smoke.

More than half of people who use medical marijuana products to ease pain also experience clusters of multiple withdrawal symptoms when they're between uses, a new study finds. And about 10% of the patients taking part in the study experienced worsening changes to their sleep, mood, mental state, energy and appetite over the next two years as they continued to use cannabis.

Female rats that inhaled vaporized cannabis daily for a month developed a blunted physiological response to stress, according to a new study. In contrast, male rats that were provided access to the same potency of cannabis over the same 30-day window did not experience any physiological changes in how they responded to a stressful situation.

Made in clandestine laboratories and sold widely across the United States, the diverse class of drugs known as synthetic cannabinoids presents a growing public health threat. In a new study, scientists have devised a way to deactivate these designer drugs after they've been administered -- offering a potential path for treating addiction and overdose.

A non-hallucinogenic version of the psychedelic drug ibogaine, with potential for treating addiction, depression and other psychiatric disorders, has been developed by researchers.

Cocaine continues to be one of the most commonly abused illicit drugs in the United States. Pre-clinical literature suggests that targeting glucagon-like peptide-1 receptors (GLP-1Rs) in the brain may represent a novel approach to treating cocaine use disorder. Specifically, GLP-1R agonists, which are FDA-approved for treating diabetes and obesity, have been shown to reduce voluntary drug taking and seeking in preclinical models of cocaine used disorder.

A new study suggests that even low doses of glucocorticoid may increase the risk of cardiovascular diseases.

Cannabidiol (CBD) oils are equally or less effective at inhibiting the growth of certain cancer cells compared to pure CBD, according to researchers. The results of their recent study indicate that future research into the clinical applications of cannabinoids should include an analysis of whether the pure cannabinoid compound or intact plant material is more effective at achieving the therapeutic effect.

Largest study on how cannabis has changed over time finds increased strength putting consumers at greater risk of harm.

In a study using genetically modified mice, researchers found that the nucleus accumbens recruited by cocaine use are largely distinct from nucleus accumbens recruited by sucrose, or table sugar. Because they are separate, this poses the possibility that drug use can be addressed without affecting biologically adaptive seeking of reward.

Taking steroid inhalers or tablets to treat asthma or control flare-ups is linked to a heightened risk of brittle bones (osteoporosis) and increased vulnerability to broken bones (fragility fractures), finds new research.

People with obsessive-compulsive disorder (OCD) report that the severity of symptoms was reduced by about half within four hours of smoking cannabis. After smoking cannabis, users with OCD reported it reduced their compulsions by 60%, intrusions, or unwanted thoughts, by 49% and anxiety by 52%. The study also found that higher doses and cannabis with higher concentrations of CBD were associated with larger reductions in compulsions.

Fewer college-age Americans drink alcohol, compared to nearly 20 years ago, according to a new study.

States may want to consider the proximity of cannabis retailers and cannabis advertising to neighborhoods to prevent underage use of the drug, according to new research.

Contrary to some claims, people in the US may not be substituting cannabis for opioids, New research examined the direction and strength of association between cannabis and opioid use among adults who used non-medical opioids. The findings showed that opioid use was at least as prevalent on days when cannabis was used as on days when it was not. The study is among the first to test opioid substitution directly.

Researchers report that older adults are increasingly using cannabis to treat a variety of common health conditions, including pain, sleep disturbances and psychiatric conditions like anxiety and depression.

Endocannabinoids, signaling molecules produced in the body that share features with chemicals found in marijuana, can shut down genes needed for some pathogenic intestinal bacteria to colonize, multiply, and cause disease, new research shows.