New research is contributing to a better understanding of the ways opiate-class drugs modify brain circuits to drive the addiction cycle. The identification of these opiate-induced changes offers the best hope for developing more effective pharmacological targets and therapies to prevent or reverse the effect of opiate exposure and addiction.
The regulated cultivation and trade of cannabis for recreational use is permissible on the basis of states’ positive human rights obligations. Pleas for the regulated cultivation and trade of recreational cannabis are often based on arguments related to individual and public health, the safety of citizens and the fight against crime: the so-called positive human rights obligations. To date, however, no study has been carried out to find out what the legal implications of legalizing cannabis would be.
Technologies that make it harder for people to abuse opioids -- like doctoring pills so that they produce unpleasant side effects if broken, crushed or injected --- likely will have limited effectiveness in stemming the global epidemic of opioid abuse,
A survey of more than 216,000 adolescents from all 50 states indicates the number of teens with marijuana-related problems is declining. Similarly, the rates of marijuana use by young people are falling despite the fact more US states are legalizing or decriminalizing marijuana use and the number of adults using the drug has increased.
A type of brain cell known as microglia plays a key role in reducing the effects of cocaine in the brain, according to a new major study. The discovery establishes for the first time that microglia can diminish the adverse changes to neural circuitry brought on by the chronic use of cocaine and has significant implications for developing an effective treatment for addiction.
The Canadian government's plan to legalize marijuana contravenes its current legal obligations to the United Nation's international drug-control conventions, states a new expert commentary.
For the first time, science has shown a direct link between continued marijuana use during pregnancy and pre-term birth. The results show that once all other major risk factors have been accounted for, continued marijuana use through to 20 weeks' gestation is independently associated with a five-fold increase in the risk of pre-term birth.
Fatal crashes involving drivers who recently used marijuana doubled in Washington after the state legalized the drug, according to the latest research. New research also shows that legal limits for marijuana and driving are arbitrary and unsupported by science, which could result in unsafe motorists going free and others being wrongfully convicted for impaired driving.
With opioid addiction and prescription drug abuse considered one of the biggest public health threats of our time in the US, many are asking why so many Americans are struggling with addiction to illegal drugs and prescription medications. New research suggests that chronic pain may be part of the answer.
An addictions expert calls on clinicians to screen for vaping among teens, who are either uninformed or misinformed about the dangers and risks associated with electronic cigarettes.
Acute Respiratory Distress Syndrome (ARDS) affects hundreds of thousands of people each year, many of them children. Now, a recent study investigates the effects of a new steroid treatment on children suffering from ARDS.
A new study found that marijuana users who were high at the time they took the survey had substantially higher odds of believing it was safe to drive while under the influence.
Imodium abuse: Anti-diarrhea medication containing loperamide dangerous for self-treatment of opiod addiction
The over-the-counter anti-diarrhea medication Imodium, or its key ingredient loperamide, is increasingly being abused by people attempting to self-treat their opioid addiction, with sometime fatal results.
Buprenorphine is a critical part of treatment for the growing epidemic of opioid abuse -- but also carries the potential for misuse and diversion. The debate over whether 'to expand or not to expand' prescribing of buprenorphine for opioid abuse is discussed in a new expert review.
In the brain, there is a delicate interplay of signaling substances and cellular activity. Scientists have now identified another key player within this ensemble. In a laboratory study they found that the 'cannabinoid type 2 receptor' influences information processing inside the hippocampus. The research results might help advance our understanding of schizophrenia and Alzheimer's, say the authors.
Despite concerns that legalizing marijuana use for adults would make it easier for adolescents to get ahold of it, a new study in Washington State shows that teens find it no easier now than before the law was passed in 2012.
A new study found that one in six infants and toddlers admitted to a Colorado hospital with coughing, wheezing and other symptoms of bronchiolitis tested positive for marijuana exposure.
A new version of an obesity drug that caused serious psychiatric side effects could help people lose pounds without experiencing the anxiety, depression and suicidal thoughts previously associated with it. The research shows that the new version of the drug can still work without reaching the brain in rats, avoiding the side effects.
Why does addiction vulnerability differ from individual to individual? For the first time, scientists have shown in selectively bred animals that the propensity for addiction is linked to differences in expression of genes for specific molecules in a specific brain region. It's also the first demonstration that a DNA tag called an epigenetic marker can predispose an individual to addiction and relapse.
Psychedelic drugs may help curb domestic violence committed by men with substance abuse problems, according to a new study. The study found that 42 percent of US adult male inmates who did not take psychedelic drugs were arrested within six years for domestic battery after their release, compared to a rate of 27 percent for those who had taken drugs such as LSD, psilocybin (commonly known as magic mushrooms) and MDMA (ecstasy).